This is certainly the matchup of the week. Mahomes and his 14 passing touchdowns go up against Jalen Ramsey’s Jacksonville Jaguars, a defense that prides itself on dominating opposing offenses. That matchup will likely decide the game. Mahomes has yet to face a defense like this in 2018, and the Jaguars haven’t faced off against a quarterback who’s playing as well as Mahomes is. The key will be getting pressure. Ramsey’s secondary unit needs to be as sturdy as they’ve been all season.